Force and Calcium Transients Analysis in Human Engineered Heart Tissues Reveals Positive Force-Frequency Relation at Physiological Frequency
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چکیده
منابع مشابه
Levosimendan restores the positive force-frequency relation in heart failure.
Frequency potentiation of contractile function is a major mechanism of the increase in myocardial performance during exercise. In heart failure (HF), this positive force-frequency relation is impaired, and the abnormal left ventricular (LV)-arterial coupling is exacerbated by tachycardia. A myofilament Ca(2+) sensitizer, levosimendan, has been shown to improve exercise tolerance in HF. This may...
متن کاملAltered myocardial force-frequency relation in human heart failure.
BACKGROUND In congestive heart failure (idiopathic dilated cardiomyopathy), exercise is accompanied by a smaller-than-normal decrease in end-diastolic left ventricular volume, depressed peak rates of left ventricular pressure rise and fall, and depressed heart-rate-dependent potentiation of contractility (bowditch treppe). We studied contractile function of isolated left ventricular myocardium ...
متن کاملPositive force- and [Ca]i-frequency relationships in rat ventricular trabeculae at physiological frequencies
Layland, Joanne, and Jonathan C. Kentish. Positive forceand [Ca]i-frequency relationships in rat ventricular trabeculae at physiological frequencies. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H9–H18, 1999.—The isometric force-frequency relationship of isolated rat ventricular trabeculae (diameter ,250 μm) was examined at 24, 30, and 37°C at stimulation frequencies (0.1–12 Hz) encompassing ...
متن کاملPositive force- and [Ca2+]i-frequency relationships in rat ventricular trabeculae at physiological frequencies.
The isometric force-frequency relationship of isolated rat ventricular trabeculae (diameter <250 μm) was examined at 24, 30, and 37°C at stimulation frequencies (0.1-12 Hz) encompassing the physiological range. Some muscles were microinjected with fura PE3 to monitor the diastolic and systolic intracellular concentration of Ca2+([Ca2+]i). At a near-physiological external Ca2+ concentration ([Ca...
متن کاملForce-Frequency Relationship in the Failing Human Heart
a reduced force of contraction in vivo and in vitro. The present study was aimed to investigate whether inotropic stimulation influences the inverse force-frequency relationship in failing human myocardium. Methods and Results. The effects of the cAMP-independent positive inotropic agents ouabain (0.01 ,imol/L) and BDF 9148 (0.1 ,umol/L) as well as the 3-adrenoceptor agonist isoprenaline (0.01 ...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2020
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2019.12.011